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Item type:Publication, Simultaneous Imaging of Ultrasonic Relative Backscatter and Attenuation Coefficients for Quantitative Liver Steatosis Assessment(Nature Research, 2023-12-01)Prevalence of liver disease is continuously increasing and nonalcoholic fatty liver disease (NAFLD) is the most common etiology. We present an approach to detect the progression of liver steatosis based on quantitative ultrasound (QUS) imaging. This study was performed on a group of 55 rats that were subjected to a control or methionine and choline deficient (MCD) diet known to induce NAFLD. Ultrasound (US) measurements were performed at 2 and 6 weeks. Thereafter, animals were humanely euthanized and livers excised for histological analysis. Relative backscatter and attenuation coefficients were simultaneously estimated from the US data and envelope signal-to-noise ratio was calculated to train a regression model for: (1) fat fraction percentage estimation and (2) performing classification according to Brunt’s criteria in grades (0 <5%; 1, 5–33%; 2, >33–66%; 3, >66%) of liver steatosis. The trained regression model achieved an R2 of 0.97 (p-value < 0.01) and a RMSE of 3.64. Moreover, the classification task reached an accuracy of 94.55%. Our results suggest that in vivo QUS is a promising noninvasive imaging modality for the early assessment of NAFLD. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Locally adapting digital health technologies to address the global challenge of Parkinson's disease(2025-08-29)Parkinson's disease is the fastest growing neurological disorder worldwide. As the global burden of the disease continues to grow, along with the environmental consequences of industrialization, it remains essential to diagnose, treat, and study Parkinson's disease among historically marginalized populations living in remote and relatively unindustrialized regions of the world. The diagnosis and monitoring of the motor manifestations of the disease depends on in-person examination of the speed, amplitude, and frequency of movement by trained providers. Digital health technologies allow synchronous, remote, video-based access to trained providers able to diagnose and monitor the progression of Parkinson's disease using clinical rating scales. Digital health technologies can be expensive, and their use requires sustainable access to trained providers, powerful computers and high-speed internet that are not widely available for historically marginalized populations, such as those living in remote Andean regions of Latin America. Local adaptation of health technologies could be promoted in partnership with historically marginalized communities to study their unique epidemiology while building local capacity to expand care and support community-driven education and research efforts.3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Performance assessment of a ventilator developed for emergency use in a resource-constrained ICU setting during the COVID-19 pandemic(BioMed Central Ltd, 2025)The Masi mechanical ventilator was developed in Peru, designed and manufactured as a rapid-response to the healthcare emergency. Its promising pre-clinical and clinical results allowed it to be approved by the national regulatory authority to be used during the emergency. The key features of Masi are its low manufacturing cost, low dependence on a supply of high volumes of oxygen, low oxygen consumption, and flexibility between non-invasive and invasive ventilation. While Masi lacks some of the advanced features found in commercial ICU ventilators, it was specifically designed for short-term use in resource-limited and high-demand situations as an alternative when conventional devices were unavailable. This study evaluates the survival rate in intubated COVID-19 patients ventilated with Masi as compared to other conventional ventilators.1