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Item type:Publication, Forgetting other communicable diseases during the COVID-19 pandemic: Tuberculosis mortality in Peru(Elsevier Ltd, 2022-05-01) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Quantitative 1H Nuclear Magnetic Resonance Assay for the Rapid Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis from Sputum Samples(American Society for Microbiology, 2023-05-01)Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the 10 leading killer diseases in the world. At least one-quarter of the population has been infected, and there are 1.3 million deaths annually. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains challenges TB treatments. One of the drugs widely used in first- and second-line regimens is pyrazinamide (PZA). Statistically, 50% of MDR and 90% of XDR clinical strains are resistant to PZA, and recent studies have shown that its use in patients with PZA-resistant strains is associated with higher mortality rates. Therefore, the is an urgent need for the development of an accurate and efficient PZA susceptibility assay. PZA crosses the M. tuberculosis membrane and is hydrolyzed to its active form, pyrazinoic acid (POA), by a nicotinamidase encoded by the pncA gene. Up to 99% of clinical PZA-resistant strains have mutations in this gene, suggesting that this is the most likely mechanism of resistance. However, not all pncA mutations confer PZA resistance, only the ones that lead to limited POA production. Therefore, susceptibility to PZA may be addressed simply by its ability to form, or not, POA. Here, we present a nuclear magnetic resonance method to accurately quantify POA directly in the supernatant of sputum cultures collected from TB patients. The ability of the clinical sputum culture to hydrolyze PZA was determined, and the results were correlated with the results of other biochemical and molecular PZA drug susceptibility assays. The excellent sensitivity and specificity values attained suggest that this method could become the new gold standard for the determination of PZA susceptibility. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Half-sandwich ruthenium (II) complexes with N,O-Quinoxaline ligand: Synthesis, in silico affinity and Mycobacterium tuberculosis susceptibility(Elsevier BV, 2026-02-01)Tuberculosis (TB) remains one of the deadliest bacterial infections, despite the approval of new anti-bacterial drugs over the past decade. This persistent challenge is attributed to the emergence of drug-resistant Mycobacterium tuberculosis strains, which emphasizes the ongoing need for novel therapeutic options. In this research, the synthesis and characterization of novel half-sandwich ruthenium (II) complexes featuring a quinoxaline-based ligand (L), 3-(4-bromophenyl)quinoxaline-2-carboxylic acid, are reported. The three complexes [Ru(p-cymene)(I)(L)] (1),[Ru(p-cymene)(Cl)(L)] (2) and [Ru(benzene)(Cl)(L)] (3) were characterized by FTIR, NMR and HRMS. Additionally, the solid-state structures of1and2were determined by XRD, revealing geometries similar to a three-legged piano stool, with the Ru atom coordinated to the carboxylate oxygen and the quinoxaline nitrogen atoms of the ligand. Interaction with mycobacterial drug targets was explored and binding energies based on docking scores were estimated to assess their potential antituberculous activity. Strong interactions were observed between1and2and the targets Emb complex and ATP synthase, suggesting potential antituberculous activity. Furthermore, the susceptibility of M. tuberculosis H37Rv strain to these compounds was evaluated by determining their minimum inhibitory concentrations (MICs). Compounds2and3each displayed MIC values of 50 μg/mL, whereas compound1exhibited a MIC of 100 μg/mL, which falls within the range observed for first-line drugs such as pyrazinamide. These findings confirm their activity against M. tuberculosis.1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gender, health-seeking, and tuberculosis: Negotiating responsibility in urban Peru(Society for Applied Anthropology, 2026-01-01)Tuberculosis (TB) remains a persistent public health concern in Peru, particularly in densely populated urban districts marked by poverty, informal labor, and overcrowded housing. Drawing on 25 semi-structured interviews with adult residents insured under the public health system (Seguro Integral de Salud) in San Juan de Lurigancho, Lima, this article examines how gender norms shape everyday understandings of TB, health-seeking practices, and moral responsibilities for care. Rather than focusing on individuals currently undergoing treatment, the study explores how TB is understood through the experiences of relatives, neighbors, coworkers, and illness trajectories within participants' social networks. Findings show that masculinities and femininities organize distinct moral economies of risk and care. Men's narratives emphasize endurance, work obligations, and the minimization of symptoms, often delaying engagement with health services, while women's accounts foreground caregiving responsibilities and the coordination of care within households. These gendered practices intersect with structural constraints, making self-medication and delayed consultation pragmatic responses to precarious everyday conditions rather than signs of neglect. By situating TB within everyday life and gendered moral expectations, this study contributes to debates on health, gender, and urban inequality. It argues for gender-sensitive public health strategies that engage with local moral worlds beyond purely informational models.1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Estigma institucional hacia personas afectadas por tuberculosis en establecimientos del primer nivel de atención de un distrito de Lima, Perú(Instituto de Salud Colectiva, Universidad Nacional de Lanús, 2026-07-16)A pesar de los avances biomédicos en el diagnóstico y tratamiento de la tuberculosis, la reproducción institucional del estigma como barrera terapéutica al tratamiento sigue siendo un problema persistente. El artículo analiza cómo se reproduce el estigma institucional hacia las personas afectadas por tuberculosis en establecimientos del primer nivel de atención de San Juan de Lurigancho, Lima. Desde un abordaje cualitativo, entre febrero y diciembre de 2025, se realizaron entrevistas semiestructuradas a 16 trabajadores de salud en seis centros de salud, observación no participante de los espacios de atención a la tuberculosis de tres centros de salud y análisis espacial de los seis centros de salud. Los hallazgos muestran que el estigma se materializa a través de tres mecanismos articulados: una arquitectura hospitalaria que hace estructuralmente imposible la confidencialidad mediante circuitos diferenciados y señalización visible; tecnologías de vigilancia epidemiológica que producen visibilidad forzada del diagnóstico; y condiciones de sobrecarga institucional que inhiben el cuidado integral. Se argumenta que abordar la adherencia al tratamiento requiere intervenir no solo en los procesos de determinación social de la salud, sino también en los dispositivos institucionales que producen y reproducen estigmatización. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Análisis de la implementación del componente de determinantes de la salud en el programa de tuberculosis: un estudio de caso en el primer nivel de atención de Lima Centro (2020-2023)(2025-05-08)This study analyzes the Tuberculosis Budget Program at the primary care level in Lima Centro (2020-2023), given its relevance in public health and social inequalities. Aligned with the 2030 SDGs and under the ESNPCT, the program aims to reduce the incidence of both drug-susceptible and multidrug-resistant tuberculosis. Despite implemented actions within a vulnerable context, concerns from users and stakeholders were identified, highlighting technical gaps despite the existing legal framework. The gap in nutritional support amid food insecurity is a concern. The MINSA, local government, and professionals are urged to create management spaces with user participation to improve the quality of care, strengthening post-pandemic strategies to decrease tuberculosis incidence and mortality.3