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Item type:Publication, Tailored peptide nanomaterials for receptor-targeted prostate cancer imaging(Royal Society of Chemistry, 2024-11-05)We report the development of a peptide-based optical nanoprobe specifically tailored for prostate cancer imaging. The imaging probe is comprised of cyclic peptide nanotubes, formed via the aqueous co-assembly of four cyclic D,L-alternating octapeptides. The inherent properties of these cyclic building blocks have been carefully selected to enhance their efficacy in imaging applications, through the addition of a cancer targeting peptide and a fluorescent dye. Comprehensive characterization using scanning electron microscopy (FESEM) and low-voltage transmission electron microscopy (LV-TEM) confirms the formation of nanotubes through co-assembly of the cyclic peptides. The resulting nanotubes show an average diameter of 28 nm. Circular dichroism (CD) spectroscopy validates the formation of stable beta-sheet hydrogen bonding structures at both 20 and 37 °C, ensuring their suitability for biomedical applications. Evaluation of PSMA-binding specificity of the resulting peptide nanotubes is assessed using confocal fluorescence microscopy demonstrating receptor-mediated uptake in prostate cancer cells. We anticipate this strategy will provide the basis for the utilization of co-assembled systems for advancing molecular imaging techniques in prostate cancer and other cancers.4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Exploring the modelling of gold anisotropic nanoparticles’ optical properties as a promising tool for detection systems design(Multidisciplinary Digital Publishing Institute (MDPI), 2024-12-01)Gold nanoparticles have been a central topic in the last few decades due to their excellent optical properties that can be exploited in many applications, including food analysis, materials science, and biomedicine. The basis of these unique optical properties is the phenomenon known as localized surface plasmon (LSP), which relays in the collective oscillation of the conduction band electrons in the nanoparticle when excited by electromagnetic radiation. The optical properties of the nanoparticles are critical for selecting the best nanomaterials for each application, a key factor for optimum performance, and can be tuned due to their dependence on the geometry and size of the nanoparticles, as well as the polarization of the light beam. Here, we conducted simulations to study the tunable optical properties and local electric field distribution of three types of gold nanoparticles, cubes (AuNC), boxes (AuNB), and triangular prisms (AuNT), which have relatively simple synthetic routes. Finally, we compared these results with experimental data and described possible synthetic routes to discuss the positive and negative aspects of using each type of nanoparticle for potential applications.1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incorporation of analytical chemistry in the undergraduate curriculum: Examples from different regions of the world(Springer Science and Business Media Deutschland GmbH, 2024-07-01)Graphical (Figure presented.)