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Item type:Publication, In vivo assessment of corneal biomechanics under a localized cross-linking treatment using confocal air-coupled optical coherence elastography(Optica Publishing Group (formerly OSA), 2022-05-01)The localized application of the riboflavin/UV-A collagen cross-linking (UV-CXL) corneal treatment has been proposed to concentrate the stiffening process only in the compromised regions of the cornea by limiting the epithelium removal and irradiation area. However, current clinical screening devices dedicated to measuring corneal biomechanics cannot provide maps nor spatial-dependent changes of elasticity in corneas when treated locally with UV-CXL. In this study, we leverage our previously reported confocal air-coupled ultrasonic optical coherence elastography (ACUS-OCE) probe to study local changes of corneal elasticity in three cases: untreated, half-CXL-treated, and full-CXL-treated in vivo rabbit corneas (n = 8). We found a significant increase of the shear modulus in the half-treated (>450%) and full-treated (>650%) corneal regions when compared to the non-treated cases. Therefore, the ACUS-OCE technology possesses a great potential in detecting spatially-dependent mechanical properties of the cornea at multiple meridians and generating elastography maps that are clinically relevant for patient-specific treatment planning and monitoring of UV-CXL procedures. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Viscoelastic characterization of in vivo human dermis using high-frequency ultrasonic crawling wave elastography(Institute of Electrical and Electronics Engineers Inc., 2022-01-01)High-frequency (center frequency of 18MHz) ultrasound was combined with crawling wave elastography to characterize skin viscoelastic properties in two anatomical sites (i.e., thigh and forearm) in humans in the range of 200-400 Hz. The Voigt model was used to obtain shear elasticity and shear viscosity estimates. The forearm's mean shear elasticity and shear viscosity were 6 kPa and 5.5 Pa.s, respectively, exhibiting significantly higher values than in the thigh (3.4 kPa and 3.2 Pa.s, respectively, p < 0.05). These results suggest that skin viscoelastic properties can be estimated in vivo using high-frequency crawling wave elastography and show translation potential for future application in the clinical screening of skin disorders. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Revealing Regional Variations in Scleral Shear Modulus in a Rabbit Eye Model Using Multi-Meridian Ultrasound Optical Coherence Elastography(RELX Group (Netherlands), 2023-01-01)